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  • R407C is NOT a “drop in” replacement in systems currently running with R22
  • R407C should NOT be mixed with R22 or any other refrigerant
  • R407C can be used in many medium-temperature refrigeration systems that formerly used R22
  • A high-quality polyol ester (POE) lubricant is recommended when using R407C
  • R407C allows the use of the same service tools as R22 systems but take extreme care to avoid cross-contamination of different types of refrigerants and lubricants